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Associate Principal Scientist - Large Molecules

Aplica ya
Mapa de ubicación: Indianapolis, Indiana, United States Full time R1233067

Descripción del trabajo


  • Design and execute large molecule bioanalytical and identification studies (PTMs, de novo) of different scaffolds (peptides, proteins, oligonucleotides, mAbs. ADCs etc) and support of drug discovery and development studies.
  • Demonstrate laboratory expertise with large molecule biologic assays (skills in protein purification and characterization, mammalian tissue processing, cell-based assays etc.) aimed at drug discovery and development.
  • Develop methods including sample preparation, chromatography and mass spectrometry approaches for the detection and quantitation of compounds; work with Thermo and Waters HRMS platforms. 
  • Communicate with clients regarding progress on scientific and operational objectives.
  • Work with management to set work plans, goals and metrics to build this service.
  • Prepare and presents project data and supporting information. Contributes to and reviews technical reports.
  • Attends scientific meetings and client visits to promote organization’s LCMS Biologics business.
  • Train less experienced scientific co-workers, when necessary, to support growth of LCMS Biologics service.
  • Oversee daily management of intra- and inter-organizational relationships to ensure timely completion of projects in accordance with customer specification.
  • Provide frequent communication of project status with clients.
  • Work with the project leader or senior leader to design & execute study strategy, maintain study schedule and focus to produce quality deliverables.
  • Work with key clients to implement this service in accordance with their expectations.


  • Bachelor’s Degree in Chemistry/Biochemistry/Pharmacy or a related field with at least 8 years’ progressively responsible related experience OR
  • Master’s degree with at least 5 years or equivalent combination of education OR 
  • Ph.D. is preferred with at least 3 years’ experience.


  • Understanding of chromatography and mass spectrometry instrumentation.
  • Understanding of all routine laboratory procedures.
  • Understanding of development/validation of methodology.
  • Understanding of wet-laboratory sample extraction.
  • Ability to interact with clients, and work to objectives/timelines.
  • Excellent attention to detail and communication skills.
  • Ability to maintain clear and efficient method development documentation.
  • Ability to provide verbally communicated or draft procedures.
  • Advanced understanding of nano-flow chromatography and modern quadrupole or orbitrap mass spectrometry instrumentation, development/validation of methodology, biological sample preparation, interpreting of data.
  • Ability to establish and maintain effective working relationships with coworkers, managers and clients.


  • Extensive use of keyboard requiring repetitive motion of fingers.
  • Extensive use of telephone and face-to-face communication requiring accurate perception of speech.
  • Regular sitting for extended periods of time.

Q² Solutions is a leading clinical trial laboratory services organization with end-to-end laboratory services and secure, enterprise-wide biospecimen and consent management solutions.

We are committed to providing equal employment opportunities for all, including veterans and candidates with disabilities.

As the COVID-19 virus continues to evolve, Q² Solutions' ability to operate and provide certain services to customers and partners necessitates Q² Solutions and its employees meet specific requirements regarding vaccination status.

Aplica ya

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